2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101400S4
    Deoxycytidine triphosphate-13C9 dilithium 98%
    Deoxycytidine triphosphate-13C9 (dCTP-13C9 dilithium; 2′-Deoxycytidine-5′-triphosphate-13C9) dilithium is 13C-labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-13C9 dilithium
  • HY-107494AR
    all-trans-4-Oxoretinoic acid (Standard) 38030-57-8
    all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
    all-trans-4-Oxoretinoic acid (Standard)
  • HY-107855S1
    DL-Mevalonolactone-d3 61219-76-9 98%
    DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling.
    DL-Mevalonolactone-d3
  • HY-108398AS
    Mead acid-d6 2692624-12-5 98%
    Mead acid-d6 is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency.
    Mead acid-d6
  • HY-108398BR
    11(Z),14(Z),17(Z)-Eicosatrienoic acid (Standard) 17046-59-2
    Isobutamben (Standard) is the analytical standard of Isobutamben. This product is intended for research and analytical applications. Isobutamben is a local anaesthetic.
    11(Z),14(Z),17(Z)-Eicosatrienoic acid (Standard)
  • HY-109120S1
    Odevixibat-13C6 98%
    Odevixibat-13C6 is 13C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis.
    Odevixibat-13C6
  • HY-111095BR
    D-(-)-Lactic acid sodium (Standard) 920-49-0
    Malvidin-3-glucoside (chloride) (Standard) is the analytical standard of Malvidin-3-glucoside (chloride). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride (Malvidin-3-O-glucoside chloride), a major wine anthocyanin, is effective in promoting resilience against stress by modulating brain synaptic plasticity and peripheral inflammation.
    D-(-)-Lactic acid sodium (Standard)
  • HY-111614S1
    Melengestrol acetate-d2 98%
    Melengestrol acetate-d2 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
    Melengestrol acetate-d2
  • HY-113147AR
    L-Palmitoylcarnitine chloride (Standard) 18877-64-0
    L-Palmitoylcarnitine (chloride) (Standard) is the analytical standard of L-Palmitoylcarnitine (chloride). This product is intended for research and analytical applications. L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].
    L-Palmitoylcarnitine chloride (Standard)
  • HY-113239S1
    rel-Hydroxycotinine-d3 159956-78-2 98%
    rel-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    rel-Hydroxycotinine-d3
  • HY-113239S2
    (Rac)-Hydroxycotinine-d3 98%
    (Rac)-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    (Rac)-Hydroxycotinine-d3
  • HY-113247S1
    Muconic acid-d4 1185239-59-1 98%
    trans-trans-Muconic acid-d4-1 is a deuterium labeled trans-trans-Muconic acid (HY-113247). trans-trans-Muconic acid is a urinary metabolite of benzene and has been used as a biomarker of exposure to benzene in human.
    Muconic acid-d4
  • HY-113252S1
    2-Methoxyestrone-13C6 98%
    2-Methoxyestrone-13C6 is the 13C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
    2-Methoxyestrone-13C6
  • HY-113365S2
    Cholestenone-13C2 82938-09-8 98%
    Cholestenone-13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells.
    Cholestenone-13C2
  • HY-113365S3
    Cholestenone-d7 2389048-48-8 98%
    Cholestenone-d7 is deuterium labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop
    Cholestenone-d7
  • HY-113367S1
    Suberylglycine-d2 1219799-02-6 98%
    Suberylglycine-d2 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.
    Suberylglycine-d2
  • HY-113407CS
    D-Fructose-6-phosphate disodium monohydrate-13C6 98%
    D-Fructose-6-phosphate disodium monohydrate-13C6 is the 13C-labeled D-Fructose-6-phosphate disodium monohydrate (HY-113407C). D-Fructose-6-phosphate disodium monohydrate is an intermediate of Glycolysis. D-Fructose-6-phosphate disodium monohydrate is the precursor for the synthesis of amino sugars, such as galactosamine and glucosamine.
    D-Fructose-6-phosphate disodium monohydrate-13C6
  • HY-113420S2
    11-Dehydro-thromboxane B2-13C5 98%
    11-Dehydro-thromboxane B2-13C5 is 13C labeled 11-Dehydro-thromboxane B2 (HY-113420). 11-Dehydro-thromboxane B2 is a platelet hemagglutinin. Thromboxane inhibition was assessed by urinary excretion levels of 11-Dehydro-thromboxane B2. 11-Dehydro-thromboxane B2 can be used in the study of atherosclerotic thrombosis.
    11-Dehydro-thromboxane B2-13C5
  • HY-113486S1
    lathosterol-d7 2260669-10-9 98%
    lathosterol-d7 is deuterium labeled Lathosterol (HY-113486). Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury.
    lathosterol-d7
  • HY-115433S1
    α-Muricholic acid-d4 98%
    α-Muricholic acid-d4 is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents.
    α-Muricholic acid-d4
Cat. No. Product Name / Synonyms Application Reactivity